Abstract |
108 patients with ischemic peripheral vascular disease were randomly allocated to receive infusion of either PGI2 (6 ng/kg/min over 8 hours daily for 5 consecutive days) or placebo in a double-blind manner. All patients had Stage II disease (Fontaine classification). One month after infusion the absolute and relative walking times were significantly (p less than 0.05) longer in the PGI2- than in the placebo-treated group. Patients were further classified as treatment responders or non-responders on the basis of increase of absolute and relative walking times. After one month 44% (24 out of 54) of the PGI2- and 15% (8 out of 54) of the placebo-treated patients were positive treatment-responders (p less than 0.01).
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Authors | I Virgolini, P Fitscha, O I Linet, J O'Grady, H Sinzinger |
Journal | Prostaglandins
(Prostaglandins)
Vol. 39
Issue 6
Pg. 657-64
(Jun 1990)
ISSN: 0090-6980 [Print] United States |
PMID | 2115186
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Clinical Trials as Topic
- Double-Blind Method
- Epoprostenol
(administration & dosage, therapeutic use)
- Exercise Test
- Follow-Up Studies
- Humans
- Infusions, Intravenous
- Intermittent Claudication
(drug therapy, physiopathology)
- Ischemia
(drug therapy, physiopathology)
- Placebos
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