CD20dim-positive T-cell large granular lymphocytic leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma.

Abstract

We report a CD20dim- positive T-cell large granular lymphocytic (T-LGL) leukemia in a patient with concurrent hairy cell leukemia and plasma cell myeloma. This patient was first diagnosed with T-LGL leukemia with dim CD20 expression, which by itself was a rare entity. He received no treatment for T-LGL leukemia. The patient later developed a hairy cell leukemia, which went into complete clinical remission after one cycle of 2-CdA. Five years later, he was diagnosed with a third malignancy, plasma cell myeloma. Complex cytogenetic aberrancies were present at the time when plasma cell myeloma was diagnosed. This is the first report, to the best of our knowledge, in the English literature with the aforementioned three distinct hematopoietic malignancies in one patient.

• Authors: Xiangdong Xu, Elizabeth H Broome, Hooman H Rashidi, Sarah T South, Marie L Dell'aquila, Huan-You Wang
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 3 Issue 8 Pg. 798-807 (Sep 12 2010) ISSN: 1936-2625 [Electronic] United States
• PMID: 21151394 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Antigens, CD20
• Antineoplastic Agents
• Rituximab

Topics

• Aged
• Antibodies, Monoclonal, Murine-Derived (therapeutic use)
• Antigens, CD20 (metabolism)
• Antineoplastic Agents (therapeutic use)
• Chromosome Aberrations
• Humans
• Leukemia, Hairy Cell (genetics, metabolism, pathology)
• Leukemia, Large Granular Lymphocytic (genetics, metabolism, pathology)
• Male
• Multiple Myeloma (genetics, metabolism, pathology)
• Neoplasms, Multiple Primary (pathology)
• Remission Induction
• Rituximab