Inhibition of follicle-stimulating hormone secretion from gonadotroph adenomas by repetitive administration of a gonadotropin-releasing hormone antagonist.

Abstract

As a preliminary step in searching for a pharmacological treatment for gonadotroph adenomas, we administered the GnRH antagonist analog Nal-Glu GnRH to five patients, four men and a woman, with FSH-secreting gonadotroph adenomas in order to determine its effect on FSH secretion. Administration of a single 10-mg dose of Nal-Glu GnRH to four of the patients produced a significant decrease in the serum FSH concentration in two patients and returned the FSH level to normal in only one. Administration of 5 mg Nal-Glu every 12 h for 7 days, however, produced a significant (P less than 0.001) decrease, and to within the normal range, in four of the five patients (mean +/- SEM, 32.7 +/- 5.6 IU/L during the 3 days before treatment and 9.8 +/- 1.4 IU/L during the last 3 days of treatment). Also, in response to the 7-day treatment, LH fell significantly in all five patients, alpha-subunit fell in three, and testosterone fell in all four men. Administration for 6 weeks of the GnRH agonist analog leuprolide did not decrease the serum FSH concentration of one of the patients whose serum FSH did decrease in response to Nal-Glu GnRH. We conclude that repetitive administration of Nal-Glu GnRH may often inhibit FSH secretion by gonadotroph adenomas and that FSH secretion by gonadotroph adenomas may be dependent on endogenous GnRH secretion.

• Authors: L Daneshdoost, S N Pavlou, M E Molitch, T A Gennarelli, P J Savino, R C Sergott, T M Bosley, J E River, W W Vale, P J Snyder
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 71 Issue 1 Pg. 92-7 (Jul 1990) ISSN: 0021-972X [Print] United States
• PMID: 2115048 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• LHRH, N-Ac-2-Nal(1)-4-Cl-Phe(2)-3-Pal(3)-Arg(5)-Glu(6)-AlaNH2(10)-
• Gonadotropin-Releasing Hormone
• Testosterone
• Luteinizing Hormone
• Follicle Stimulating Hormone
• Leuprolide

Topics

• Adenoma (metabolism, surgery)
• Adult
• Aged
• Amino Acid Sequence
• Dose-Response Relationship, Drug
• Female
• Follicle Stimulating Hormone (blood, metabolism)
• Gonadotropin-Releasing Hormone (administration & dosage, analogs & derivatives, antagonists & inhibitors, metabolism, pharmacology)
• Humans
• Leuprolide
• Luteinizing Hormone (blood)
• Male
• Middle Aged
• Molecular Sequence Data
• Paraneoplastic Endocrine Syndromes (drug therapy)
• Pituitary Neoplasms (metabolism, surgery)
• Testosterone (metabolism)
• Time Factors
• Tumor Cells, Cultured (drug effects)