Dietary supplementation with d-tagatose in subjects with type 2 diabetes leads to weight loss and raises high-density lipoprotein cholesterol.

Abstract

Oral d-tagatose (d-tag) attenuates the rise in plasma glucose during an oral glucose tolerance test in subjects with type 2 diabetes mellitus (DM) and reduces food intake in healthy human subjects. A reduction in food consumption and less weight gain occur in rats fed tagatose. This pilot study explored the metabolic effects of d-tag given daily to 8 human subjects with type 2 DM for 1 year. We hypothesized that this treatment period would lead to weight loss and improvements in glycated hemoglobin and the lipid profile. A 2-month run-in period was followed by a 12-month treatment period when 15 g of oral d-tag was taken 3 times daily with food. No serious adverse effects were seen during the 12-month treatment period. Ten of the initially 12 recruited subjects experienced gastrointestinal side effects that tended to be mild and transient. When 3 subjects were excluded who had oral diabetes, medications added and/or dosages increased during the study and mean (SD) body weight declined from 108.4 (9.0) to 103.3 (7.3) kg (P = .001). Glycated hemoglobin fell nonsignificantly from 10.6% ± 1.9% to 9.6% ± 2.3% (P = .08). High-density lipoprotein cholesterol progressively rose from a baseline level of 30.5 ± 15.8 to 41.7 ± 12.1 mg/dL at month 12 in the 6 subjects who did not have lipid-modifying medications added during the study (P < .001). Significant improvements in body weight and high-density lipoprotein cholesterol in this pilot study suggest that d-tag may be a potentially useful adjunct in the management of patients with type 2 DM.

• Authors: Thomas W Donner, Laurence S Magder, Kiarash Zarbalian
• Journal: Nutrition research (New York, N.Y.) (Nutr Res) Vol. 30 Issue 12 Pg. 801-6 (Dec 2010) ISSN: 1879-0739 [Electronic] United States
• PMID: 21147362 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2010 Elsevier Inc. All rights reserved.

Chemical References

• Cholesterol, HDL
• Glycated Hemoglobin A
• Hexoses
• Hypoglycemic Agents
• tagatose

Topics

• Adult
• Aged
• Cholesterol, HDL (blood)
• Diabetes Mellitus, Type 2 (blood, drug therapy, physiopathology)
• Dietary Supplements
• Drug Therapy, Combination
• Female
• Gastrointestinal Diseases (etiology)
• Glycated Hemoglobin (metabolism)
• Hexoses (pharmacology, therapeutic use)
• Humans
• Hypoglycemic Agents (pharmacology, therapeutic use)
• Male
• Middle Aged
• Pilot Projects
• Weight Loss (drug effects)