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[Preventional and therapeutic effects of aldose reductase inhibitor FR74366 on rat galactose cataract].

Abstract
Preventional and reversal effects of a new aldose reductase inhibitor FR74366 on the rat galactose cataract were examined biochemically and light microscopically. A high concentration (0.075%) FR74366 showed sufficient effects both to prevent and reverse cataract, but low concentrations (0.025%) FR74366 was not effective as 0.075% FR74366. These results indicate that FR74366 can be useful drug for cataract.
AuthorsT Tsuji, Y Matsumoto, K Mori, H Ikebe, H Terubayashi, Y Akagi, T Tanimoto
JournalNippon Ganka Gakkai zasshi (Nippon Ganka Gakkai Zasshi) Vol. 94 Issue 2 Pg. 120-7 (Feb 1990) ISSN: 0029-0203 [Print] Japan
PMID2114732 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Quinazolines
  • FR 74366
  • Sugar Alcohol Dehydrogenases
  • Aldehyde Reductase
  • Galactose
Topics
  • Aldehyde Reductase (antagonists & inhibitors)
  • Animals
  • Cataract (drug therapy, pathology, prevention & control)
  • Galactose
  • Quinazolines (therapeutic use)
  • Rats
  • Sugar Alcohol Dehydrogenases (antagonists & inhibitors)

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