Relationship between schistosomicidal drug efficacy, gonadal steroid hormonal changes and state of disease immunopathology in murine schistosomiasis mansoni.

Abstract

The schistosomicidal efficacy of praziquantel (2 x 500 mg/kg), oxamniquine (1 x 100 mg/kg) and combined one-third the curative dose of each of them (333 mg/kg praziquantel + 33 mg/kg oxamniquine), were correlated to gonadal steroid hormonal changes and state of disease immunopathology, in mice infected with 100 Schistosoma mansoni (S. mansoni) cercariae. Maximum efficacy recorded with combination regimen particularly 4 weeks after treatment, was accompanied by maximum reduction in granuloma volume (65%), least fall in testosterone level (-56.2 and -60.2% in male and female mice respectively) and increased progesterone level (+33.9 and +81.5% in male and female mice respectively). These findings revealed a potentiated effect of combination therapy on mature infection and the possible involvement of gonadal steroid hormones in affecting the efficacy of schistosomicidal drugs and state of disease immunopathology.

• Authors: S S Botros, S H Salama, M Y Estafan, N E Gomaa, A A Metwally, F A Ebeid
• Journal: Pharmacological research (Pharmacol Res) 1990 May-Jun Vol. 22 Issue 3 Pg. 359-70 ISSN: 1043-6618 [Print] Netherlands
• PMID: 2114615 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Nitroquinolines
• Schistosomicides
• Oxamniquine
• Testosterone
• Progesterone
• Estradiol
• Praziquantel

Topics

• Animals
• Drug Administration Schedule
• Drug Therapy, Combination
• Estradiol (blood)
• Female
• Male
• Mice
• Nitroquinolines (pharmacology)
• Oxamniquine (administration & dosage, pharmacology)
• Praziquantel (administration & dosage, pharmacology)
• Progesterone (blood)
• Schistosoma mansoni (drug effects)
• Schistosomiasis mansoni (blood, immunology, pathology)
• Schistosomicides (pharmacology)
• Testosterone (blood)