[Epidemiological study of Klebsiella spp. uropathogenic strains producing extended-spectrum β-lactamase in a Tunisian university hospital, 2009].

Abstract

OBJECTIVE:

An update on the prevalence of antibiotic resistance in extended-spectrum β-lactamase among urinary strains of Klebsiella spp. isolated from in-come and out-come patients at University Hospital, Mahdia (Tunisia).

PATIENTS AND METHODS:

A retrospective survey was made over a period of twelve months (year 2009). It focused on 3564 patients with urinary tract infection confirmed by the Laboratory of Microbiology in the University Hospital, Mahdia.

RESULTS:

Klebsiella spp. was involved in 5.5% (198/3564) of all cases of urinary tract infections identified. Klebsiella pneumoniae accounted for 94.9% of all Klebsiella (5.1% for Klebsiella oxytoca). The frequency of Klebsiella spp. resistance to fluoroquinolones was 19.2% and to third generation cephalosporins was 22.7%. Forty strains of Klebsiella spp. producing extended-spectrum β-lactamase witch corresponds to 20.2% of all the Klebsiella. The extended-spectrum β-lactamase strains with resistance to fluoroquinolones were 67.5% (27/40) or 13.6% of all klebsiella (27/198). No strain was resistant to imipenem. The 27 strains multiresistant (ESBL+FQ resistance) are likely to be carriers of plasmids encoding the ESBL and resistance to fluoroquinolones.

CONCLUSION:

the resistance of Enterobacteriaceae, including Klebsiella spp, to fluoroquinolones has become a concern both in hospital in community medicine. The advent of this resistance mechanism involves a more rational use of fluoroquinolones, especially as first-line treatment of urinary tract infections.

• Authors: A Ben Haj Khalifa, M Khedher
• Journal: Pathologie-biologie (Pathol Biol (Paris)) Vol. 60 Issue 2 Pg. e1-5 (Apr 2012) ISSN: 1768-3114 [Electronic] France
• Vernacular Title: Epidémiologie des souches de Klebsiella spp. uropathogènes productrices de β-lactamases à spectre élargi dans un hôpital universitaire Tunisien, 2009.
• PMID: 21145175 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• beta-Lactamases

Topics

• Cross Infection (epidemiology, microbiology)
• Female
• Hospital Units (statistics & numerical data)
• Hospitals, University
• Humans
• Klebsiella (classification, isolation & purification, metabolism)
• Klebsiella Infections (epidemiology, microbiology)
• Klebsiella oxytoca (isolation & purification, physiology)
• Klebsiella pneumoniae (isolation & purification, physiology)
• Male
• Microbial Sensitivity Tests
• Retrospective Studies
• Tunisia (epidemiology)
• Urinary Tract Infections (epidemiology, microbiology)
• beta-Lactamases (metabolism)