[Inulicin inhibits activation and expression of vascular remodeling enzymes induced by de-endothelium].

Abstract

AIM:

To observe the effects of inulicin on the neointimal hyperplasia and expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) after balloon injury in rat aorta.

METHODS:

The intimal hyperplasia model was replicated by balloon injury. The histological changes in vascular wall were observed by HE staining. MMP-2 activation was tested by gelatin zymogram analysis; MMP-2 and TIMP-2 expression was detected by Western blot and immunohistochemistry analysis.

RESULTS:

Neointimal hyperplasia induced by balloon injury was significantly inhibited by inulicin. The proteolytic activity and the expression of MMP-2 and ratio of MMP-2 and TIMP-2 were also returned to control level by inulicin after balloon injury.

CONCLUSION:

Inulicin inhibits hyperplasia of neointima by modulating the balance of MMP-2 and TIMP-2.

• Authors: Juan-Juan Li, Jin-Kun Wen, Mei Han
• Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (Zhongguo Ying Yong Sheng Li Xue Za Zhi) Vol. 24 Issue 2 Pg. 156-60 (May 2008) ISSN: 1000-6834 [Print] China
• PMID: 21141515 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Sesquiterpenes
• Tissue Inhibitor of Metalloproteinase-2
• inulicin
• Matrix Metalloproteinase 2
• Mmp2 protein, rat

Topics

• Animals
• Endothelium, Vascular (drug effects, enzymology, metabolism)
• Hyperplasia (prevention & control)
• Male
• Matrix Metalloproteinase 2 (metabolism)
• Neointima (prevention & control)
• Rats
• Rats, Sprague-Dawley
• Sesquiterpenes (pharmacology)
• Tissue Inhibitor of Metalloproteinase-2 (metabolism)