Efficacy of latanoprost in management of chronic angle closure glaucoma.

Abstract

BACKGROUND:

chronic angle closure glaucoma is often managed surgically.

AIM:

to study the effect of Latanoprost 0.005% on intraocular pressure in subjects diagnosed as having chronic angle closure glaucoma.

MATERIALS AND METHODS:

forty patients participated in the study. Baseline examination included visual acuity, refraction, slit-lamp examination, intraocular pressure, anterior and posterior segment examination, gonioscopy and perimetry. Patients were treated with Latanoprost 0.005% once daily at bedtime. IOP was recorded at baseline, 2weeks, 4 weeks, 8 weeks and 12 weeks after starting the treatment.

RESULTS:

the mean age of the study sample was 56.45 years (40-70 years). There were 18 males and 22 females in the study. Mean IOP at baseline was 24.55 +/- 3.63. Mean IOP decreased to 17.27 +/- 3.19 at 2 weeks, 15.27 +/- 3.07 at 4 weeks, 14.60-3.06 at 8 weeks and 14.47 +/- 2.66 at 12 weeks. There was a statistically significant reduction in mean IOP (41.03%) at 12 weeks as compared to those of the baseline IOP (p=0.000). There was no significant difference in IOP reduction in eyes with different degrees of angle closure by peripheral anterior synechiae.

CONCLUSION:

latanoprost, a prostaglandin analogue, is effective in reducing IOP in chronic angle closure glaucoma patients and its efficacy is not affected by the degree of angle closure by peripheral anterior synechiae.

• Authors: S Kumar, A Malik, M Singh, S Sood
• Journal: Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH (Nepal J Ophthalmol) 2009 Jan-Jun Vol. 1 Issue 1 Pg. 32-6 ISSN: 2072-6805 [Print] Nepal
• PMID: 21141019 (Publication Type: Comparative Study, Journal Article, Multicenter Study)

Chemical References

• Antihypertensive Agents
• Prostaglandins F, Synthetic
• Latanoprost

Topics

• Adult
• Aged
• Antihypertensive Agents (administration & dosage, therapeutic use)
• Chronic Disease
• Female
• Follow-Up Studies
• Glaucoma, Angle-Closure (drug therapy, physiopathology)
• Gonioscopy
• Humans
• Intraocular Pressure (drug effects)
• Latanoprost
• Male
• Middle Aged
• Prostaglandins F, Synthetic (administration & dosage, therapeutic use)
• Treatment Outcome