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Therapeutic activity of two xanthones in a xenograft murine model of human chronic lymphocytic leukemia.

AbstractBACKGROUND:
We previously reported that allanxanthone C and macluraxanthone, two xanthones purified from Guttiferae trees, display in vitro antiproliferative and proapoptotic activities in leukemic cells from chronic lymphocytic leukemia (CLL) and leukemia B cell lines.
RESULTS:
Here, we investigated the in vivo therapeutic effects of the two xanthones in a xenograft murine model of human CLL, developed by engrafting CD5-transfected chronic leukemia B cells into SCID mice. Treatment of the animals with five daily injections of either allanxanthone C or macluraxanthone resulted in a significant prolongation of their survival as compared to control animals injected with the solvent alone (p = 0.0006 and p = 0.0141, respectively). The same treatment of mice which were not xenografted induced no mortality.
CONCLUSION:
These data show for the first time the in vivo antileukemic activities of two plant-derived xanthones, and confirm their potential interest for CLL therapy.
AuthorsSéverine Loisel, Karine Le Ster, Michèle Meyer, Christian Berthou, Pierre Youinou, Jean-Pierre Kolb, Christian Billard
JournalJournal of hematology & oncology (J Hematol Oncol) Vol. 3 Pg. 49 (Dec 07 2010) ISSN: 1756-8722 [Electronic] England
PMID21138552 (Publication Type: Journal Article)
Chemical References
  • Xanthones
  • allanxanthone C
Topics
  • Animals
  • Cell Line, Tumor
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell (drug therapy)
  • Mice
  • Mice, SCID
  • Xanthones (pharmacology)
  • Xenograft Model Antitumor Assays

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