Abstract | BACKGROUND:
Ovarian cancer is the second most common cancer of the female genital tract in the United Kingdom (UK), accounting for 6% of female deaths due to cancer. This cancer is associated with poor survival and there is a need for new treatments in addition to existing chemotherapy to improve survival. Potassium (K+) channels have been shown to be overexpressed in various cancers where they appear to play a role in cell proliferation and progression. OBJECTIVES: METHODS: RESULTS: We show for the first time that high expression of Eag channels in ovarian cancer patients is significantly associated with poor survival (P = 0.016) unlike HERG channel expression where there was no correlation with survival. There was also a significant association of Eag staining with high tumour grade (P = 0.014) and presence of residual disease (P = 0.011). Proliferation of SK-OV-3 cells was significantly (P < 0.001) inhibited after treatment with voltage gated K+ channel blockers. CONCLUSION: This novel finding demonstrates a role for Eag as a prognostic marker for survival in patients with ovarian cancer.
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Authors | Viren Asher, Raheela Khan, Averil Warren, Robert Shaw, Gerhard V Schalkwyk, Anish Bali, Heidi M Sowter |
Journal | Diagnostic pathology
(Diagn Pathol)
Vol. 5
Pg. 78
(Dec 07 2010)
ISSN: 1746-1596 [Electronic] England |
PMID | 21138547
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels
- KCNH2 protein, human
- Potassium Channel Blockers
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Biopsy
- Cell Line, Tumor
- Cell Proliferation
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels
(antagonists & inhibitors, metabolism)
- Female
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Middle Aged
- Neoplasm Staging
- Ovarian Neoplasms
(metabolism, mortality, pathology, therapy)
- Potassium Channel Blockers
(pharmacology)
- Time Factors
- Tissue Array Analysis
- Treatment Outcome
- Up-Regulation
- Young Adult
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