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The Eag potassium channel as a new prognostic marker in ovarian cancer.

AbstractBACKGROUND:
Ovarian cancer is the second most common cancer of the female genital tract in the United Kingdom (UK), accounting for 6% of female deaths due to cancer. This cancer is associated with poor survival and there is a need for new treatments in addition to existing chemotherapy to improve survival. Potassium (K+) channels have been shown to be overexpressed in various cancers where they appear to play a role in cell proliferation and progression.
OBJECTIVES:
To determine the expression of the potassium channels Eag and HERG in ovarian cancer tissue and to assess their role in cell proliferation.
METHODS:
The expression of Eag and HERG potassium channels was examined in an ovarian cancer tissue microarray. Their role in cell proliferation was investigated by blocking voltage-gated potassium channels in an ovarian cancer cell line (SK-OV-3).
RESULTS:
We show for the first time that high expression of Eag channels in ovarian cancer patients is significantly associated with poor survival (P = 0.016) unlike HERG channel expression where there was no correlation with survival. There was also a significant association of Eag staining with high tumour grade (P = 0.014) and presence of residual disease (P = 0.011). Proliferation of SK-OV-3 cells was significantly (P < 0.001) inhibited after treatment with voltage gated K+ channel blockers.
CONCLUSION:
This novel finding demonstrates a role for Eag as a prognostic marker for survival in patients with ovarian cancer.
AuthorsViren Asher, Raheela Khan, Averil Warren, Robert Shaw, Gerhard V Schalkwyk, Anish Bali, Heidi M Sowter
JournalDiagnostic pathology (Diagn Pathol) Vol. 5 Pg. 78 (Dec 07 2010) ISSN: 1746-1596 [Electronic] England
PMID21138547 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • ERG1 Potassium Channel
  • Ether-A-Go-Go Potassium Channels
  • KCNH2 protein, human
  • Potassium Channel Blockers
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (metabolism)
  • Biopsy
  • Cell Line, Tumor
  • Cell Proliferation
  • ERG1 Potassium Channel
  • Ether-A-Go-Go Potassium Channels (antagonists & inhibitors, metabolism)
  • Female
  • Humans
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Middle Aged
  • Neoplasm Staging
  • Ovarian Neoplasms (metabolism, mortality, pathology, therapy)
  • Potassium Channel Blockers (pharmacology)
  • Time Factors
  • Tissue Array Analysis
  • Treatment Outcome
  • Up-Regulation
  • Young Adult

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