Liver proteins as sensor of human malignancies and inflammation.

Abstract

In this review we would like to highlight the importance of acute-phase proteins as sensor of diseases. Both acute-phase protein levels and glycosylation have been reported to be altered in inflammation and other diseases including cancer. Factors that promote acute-phase protein synthesis and enhance the expression of specific glycosyltransferases, such as sialyltransferases and fucosyltransferases, may be up-regulated in some tumours and would explain the changes in acute-phase protein levels and the specific N-glycosylation modifications of some acute-phase proteins in cancer. However, further studies are required to define the potential clinical application of these acute-phase protein cancer-specific modifications as possible cancer diagnostic or monitoring tools.

• Authors: Rosa Peracaula, Ariadna Sarrats, Pauline M Rudd
• Journal: Proteomics. Clinical applications (Proteomics Clin Appl) Vol. 4 Issue 4 Pg. 426-31 (Apr 2010) ISSN: 1862-8354 [Electronic] Germany
• PMID: 21137061 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Acute-Phase Proteins
• Biomarkers

Topics

• Acute-Phase Proteins (analysis)
• Biomarkers (blood)
• Humans
• Inflammation
• Liver (pathology)
• Liver Neoplasms (diagnosis, pathology)