Proneurotensin/neuromedin N secreted from small cell lung carcinoma cell lines as a potential tumor marker.

Abstract

Proteins secreted from specific cancer cells have a high potential for use as tumor markers. We identified secreted proteins produced by 15 different carcinoma cell lines grown in serum-free medium using MS/MS. Proneurotensin/neuromedin N (proNT/NMN) was found in conditioned medium from four of seven small cell lung carcinoma cell lines but not from eight nonsmall cell lung carcinoma cell lines. These results indicate proNT/NMN has potential as a specific tumor marker of small cell lung carcinoma.

• Authors: Shun-Ichiro Ogura, Kumi Kaneko, Shoji Miyajima, Keiichi Ohshima, Ken Yamaguchi, Tohru Mochizuki
• Journal: Proteomics. Clinical applications (Proteomics Clin Appl) Vol. 2 Issue 12 Pg. 1620-7 (Dec 2008) ISSN: 1862-8346 [Print] Germany
• PMID: 21136812 (Publication Type: Journal Article)
• Copyright: Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.