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Effect of percutaneous transluminal angioplasty on tissue oxygenation in ischemic diabetic feet.

Abstract
Percutaneous transluminal angioplasty (PTA) has been performed as an alternative to bypass surgery for improving tissue oxygenation in ischemic diabetic feet because the former is less invasive than the latter. The purpose of this study was to evaluate the effect of PTA on tissue oxygenation in ischemic diabetic feet. This study included 29 ischemic diabetic feet, as determined by a transcutaneous oxygen pressure (TcPO(2) )<30 mmHg. The PTA was carried out in 29 limbs. The PTA procedure was considered successful, acceptable, and failed when residual stenosis was<30%, between 30 and 50%, and>50%, respectively. For evaluation of tissue oxygenation, the foot TcPO(2) was measured before PTA and weekly for 6 weeks after PTA. Immediately after PTA, 26 feet were evaluated as being successful and the remaining three as acceptable. Before PTA, the average foot TcPO(2) was 12.7 ± 8.9 mmHg. The TcPO(2) values were increased to 43.6 ± 24.1, 51.0 ± 22.6, 58.3 ± 23.0, 61.3 ± 24.2, 59.0 ± 22.2, and 53.8 ± 21.0 mmHg 1, 2, 3, 4, 5, and 6 weeks after PTA, respectively (p<0.01). The PTA procedure significantly increases tissue oxygenation in ischemic diabetic feet. The maximal level of tissue oxygenation was measured on the fourth week following PTA.
AuthorsHong-Ryul Kim, Seung-Kyu Han, Seung-Woon Rha, Hyun-Surk Kim, Woo-Kyung Kim
JournalWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (Wound Repair Regen) 2011 Jan-Feb Vol. 19 Issue 1 Pg. 19-24 ISSN: 1524-475X [Electronic] United States
PMID21134031 (Publication Type: Clinical Trial, Journal Article)
Copyright© 2010 by the Wound Healing Society.
Topics
  • Aged
  • Aged, 80 and over
  • Angioplasty
  • Arterial Occlusive Diseases (etiology, metabolism, therapy)
  • Blood Gas Monitoring, Transcutaneous
  • Cohort Studies
  • Diabetic Foot (etiology, metabolism, therapy)
  • Female
  • Foot (blood supply)
  • Humans
  • Ischemia (etiology, metabolism, therapy)
  • Male
  • Middle Aged
  • Oxygen Consumption (physiology)
  • Time Factors
  • Treatment Outcome

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