[Therapy control of specific hymenoptera venom allergy].

In Germany anaphylactic reactions after insect stings are mostly caused by honey bee (Apis mellifera) and wasp (Vespula vulgaris, Vespula germanica). In the majority of cases venom immunotherapy is a successful therapy and protects patients from recurrent systemic anaphylactic reaction. In some patients persistent severe reactions after insect sting can even occur in spite of venom therapy, as a sign of therapy failure. It is important to identify these patients, who do not benefit from venom immunotherapy, in an early stage of therapy. In this case dose rate of venom immunotherapy must be adjusted for a successful therapy outcome. Up to now skin prick tests, specific IgE-antibodies and in vitro diagnostics are not suitable for detecting therapy failure. Patients with treatment failure can be diagnosed by insect sting test and almost all of them will become fully protected by increasing the maintenance dose.
AuthorsW Aust, G Wichmann, A Dietz
JournalLaryngo- rhino- otologie (Laryngorhinootologie) Vol. 89 Issue 12 Pg. 725-8 (Dec 2010) ISSN: 1438-8685 [Electronic] Germany
Vernacular TitleTherapiekontrolle der Insektengifthyposensibilisierung.
PMID21132618 (Publication Type: English Abstract, Journal Article, Review)
Copyright© Georg Thieme Verlag KG Stuttgart · New York.
Chemical References
  • Bee Venoms
  • Wasp Venoms
  • Anaphylaxis (immunology, prevention & control)
  • Animals
  • Bee Venoms (immunology)
  • Bees
  • Desensitization, Immunologic (methods)
  • Dose-Response Relationship, Drug
  • Follow-Up Studies
  • Humans
  • Injections, Subcutaneous
  • Insect Bites and Stings (complications, immunology)
  • Intradermal Tests
  • Treatment Failure
  • Treatment Outcome
  • Wasp Venoms (administration & dosage, immunology)
  • Wasps

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