In vivo effects of single or combined dietary antimutagens on mutagen-induced chromosomal aberrations.

Abstract

The food components chlorophyllin, beta-carotene and alpha-linolenic acid (in its methyl ester form) were tested in Chinese hamsters for antimutagenic activity on the powerful mutagen thio-tepa. Each of these natural protective compounds inhibited by 70-85% the clastogenic effects induced by the mutagen. When 2 or 3 of these antimutagens were administered simultaneously no additive effects were observed. alpha-Linolenic acid methyl ester was the most effective antimutagen under the experimental conditions.

• Authors: H W Renner
• Journal: Mutation research (Mutat Res) Vol. 244 Issue 2 Pg. 185-8 (Jun 1990) ISSN: 0027-5107 [Print] Netherlands
• PMID: 2113182 (Publication Type: Journal Article)

Chemical References

• Chlorophyllides
• Linoleic Acids
• beta Carotene
• Chlorophyll
• methyl linoleate
• Carotenoids
• Thiotepa
• chlorophyllin

Topics

• Animals
• Carotenoids (pharmacology)
• Chlorophyll (analogs & derivatives)
• Chlorophyllides (pharmacology)
• Chromosome Aberrations
• Cricetinae
• Linoleic Acids (pharmacology)
• Thiotepa (antagonists & inhibitors, toxicity)
• beta Carotene