Abstract | CONTEXT: OBJECTIVE: DESIGN: Cross-sectional and longitudinal analyses of a prospective cohort study. SETTING: Four U.S. centers. PARTICIPANTS: 6307 women aged≥69 years. MAIN OUTCOME MEASURES:
Frailty status classified as robust, intermediate stage, or frail at baseline; and robust, intermediate stage, frail, or dead (all-cause mortality) at follow-up an average of 4.5 years later. RESULTS: At baseline, there was a U-shaped association between 25( OH)D level and odds of frailty with the lowest risk among women with levels 20.0-29.9 ng/ml (referent group). Compared with this group, the odds of frailty were higher among those with levels<15.0 ng/ml [multivariable odds ratio (MOR) 1.47, 95% confidence interval (CI), 1.19-1.82], those with levels 15.0-19.9 ng/ml (MOR 1.24, 95% CI 0.99-1.54), and those with levels≥30 ng/ml (MOR 1.32, 95% CI 1.06-1.63). Among 4551 nonfrail women at baseline, the odds of frailty/death (vs. robust/intermediate) at follow-up appeared higher among those with levels 15.0-19.9 ng/ml (MOR 1.21, 95% CI 0.99-1.49), but the CI overlapped 1.0. The odds of death (vs. robust/intermediate/frail at follow-up) was higher among those with levels<15.0 ng/ml (MOR 1.40, 95% CI 1.04-1.88) and those with levels 15.0-19.9 ng/ml (MOR 1.30, 95% CI 0.97-1.75), although the latter association did not quite reach significance. CONCLUSION: Lower (<20 ng/ml) and higher (≥30 ng/ml) levels of 25( OH)D among older women were moderately associated with a higher odds of frailty at baseline. Among nonfrail women at baseline, lower levels (<20 ng/ml) were modestly associated with an increased risk of incident frailty or death at follow-up.
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Authors | Kristine E Ensrud, Susan K Ewing, Lisa Fredman, Marc C Hochberg, Jane A Cauley, Teresa A Hillier, Steven R Cummings, Kristine Yaffe, Peggy M Cawthon, Study of Osteoporotic Fractures Research Group |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 95
Issue 12
Pg. 5266-73
(Dec 2010)
ISSN: 1945-7197 [Electronic] United States |
PMID | 21131545
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Calcium, Dietary
- Ergocalciferols
- Vitamin D
- Cholecalciferol
- 25-hydroxyvitamin D
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Topics |
- Aged
- Alcohol Drinking
- Calcium, Dietary
- Cholecalciferol
(blood)
- Cross-Sectional Studies
- Ergocalciferols
(blood)
- Female
- Follow-Up Studies
- Frail Elderly
(statistics & numerical data)
- Health Status
- Humans
- Longitudinal Studies
- Odds Ratio
- Prevalence
- Risk Assessment
- Smoking
(epidemiology)
- Vitamin D
(analogs & derivatives, blood)
- Vitamin D Deficiency
(complications)
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