Abstract | BACKGROUND: METHODS: Data on 310 consecutive lung transplant patients, which were prospectively collected, were analyzed. The main outcome variables were all-cause mortality and primary graft dysfunction. Patients were grouped according to donor organ preservation solution, either Euro-Collins, Papworth solution or Perfadex. Multivariate analysis with an additional sensitivity analysis utilizing a propensity score for the use of Papworth solution was performed. RESULTS: Papworth solution was associated with significantly increased mortality compared with the other preservation solutions [odds ratio (OR) = 2.36 (1.21 to 4.58), p = 0.01]. Perfadex was associated with a reduced incidence of primary graft dysfunction at 48 hours (OR = 0.23 [0.08 to 0.68], p = 0.008). Increasing donor age was also associated with increased risk of death (OR = 1.03 [1.01 to 1.04], p = 0.004). CONCLUSION: Papworth solution for donor lung preservation is associated with an increased mortality in lung transplant recipients.
|
Authors | Silvana F Marasco, Michael Bailey, Daniel McGlade, Greg Snell, Glen Westall, Takahiro Oto, David Pilcher |
Journal | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
(J Heart Lung Transplant)
Vol. 30
Issue 4
Pg. 414-9
(Apr 2011)
ISSN: 1557-3117 [Electronic] United States |
PMID | 21131216
(Publication Type: Comparative Study, Journal Article)
|
Copyright | Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Organ Preservation Solutions
|
Topics |
- Female
- Humans
- Lung Transplantation
(mortality)
- Male
- Middle Aged
- Organ Preservation Solutions
- Primary Graft Dysfunction
(etiology, mortality)
- Retrospective Studies
|