Abstract | AIMS: METHODS: The right middle cerebral artery was occluded for 2h, and the infarct size was determined 24h after reperfusion of cerebral blood flow. Brain oedema was evaluated by comparing the area of the right hemisphere to that of the left hemisphere. RESULTS: Focal cerebral ischaemia provoked marked damage in saline-treated control rats, and infarct volumes in the striatum and cerebral cortex were 56 (49-63) mm(3) and 110 (72-148) mm(3), respectively (means and 95% confidence intervals, n=6). Administration of l-histidine (1000mg/kg, intraperitoneal) immediately after reperfusion did not affect the infarct size. Simultaneous administration of diphenhydramine (20mg/kg, intraperitoneal) with l-histidine reduced the infarct size to 25% and 21% of that in the control group, respectively. The combination therapy completely reduced ischaemia-induced brain oedema. CONCLUSION:
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Authors | Naoto Adachi, Keyue Liu, Kanji Ninomiya, Eiko Matsuoka, Atsuko Motoki, Yumi Irisawa, Masahiro Nishibori |
Journal | Resuscitation
(Resuscitation)
Vol. 82
Issue 2
Pg. 219-21
(Feb 2011)
ISSN: 1873-1570 [Electronic] Ireland |
PMID | 21131122
(Publication Type: Journal Article)
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Copyright | Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Histamine H1 Antagonists
- Histidine
- Diphenhydramine
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Topics |
- Animals
- Brain Infarction
(etiology, pathology, prevention & control)
- Brain Ischemia
(complications)
- Diphenhydramine
(administration & dosage)
- Drug Therapy, Combination
- Histamine H1 Antagonists
(administration & dosage)
- Histidine
(administration & dosage)
- Male
- Rats
- Rats, Wistar
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