Additive benefit of glycoprotein IIb/IIIa inhibition and adjunctive thrombus aspiration during primary coronary intervention: results of the Initial Thrombosuction and Tirofiban Infusion (ITTI) trial.

Abstract

BACKGROUND:

Thrombus aspiration has been shown to provide significant benefits during primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). The aim of the current study was to evaluate the additional benefit of tirofiban to thrombus aspiration during primary PCI in myocardial reperfusion.

METHODS:

100 STEMI patients were randomized according to a 2 × 2 factorial design into 1 of the 4 groups: standard PCI, PCI with initial thrombus aspiration (IT), PCI with tirofiban infusion (TI), and PCI with both treatments (IT+TI).

RESULTS:

The myocardial blush grade (MBG) 3 was achieved in 30.4%, 45.8%, 56% and 78.6% in the 4 groups respectively. More frequent MBG 3 (p=0.015) and complete (>70%) ST-segment resolution (STR, 67.9% vs. 41.7%, p=0.058) were observed in IT ± TI group compared with IT group. If actuarial analysis was done after reassigning the 2 TI patients who crossed over to IT+TI, the difference between IT+TI and IT groups became more significant (MBG 3 rates: 76.7% vs. 45.8%, p=0.009; complete STR rates: 70% vs. 41.7%, p=0.036). Infusion of tirofiban resulted in improved MBG and STR (p=0.003 and 0.037, respectively). Thrombus aspiration resulted in improved MBG only (p=0.048) but not in STR. 6-month MACE (death, reinfarction, target lesion revascularization and stroke) was similar among groups (p=0.725).

CONCLUSIONS:

Tirofiban may augment thrombus aspiration therapy on myocardial reperfusion in primary PCI. The benefit of thrombus aspiration treatment without tirofiban might be less significant, especially on resolution of ST-segment elevation.

• Authors: Chung-Pin Liu, Mao-Shin Lin, Yu-Wei Chiu, Jen-Kuang Lee, Chih-Neng Hsu, Chi-Shen Hung, Hsien-Li Kao
• Journal: International journal of cardiology (Int J Cardiol) Vol. 156 Issue 2 Pg. 174-9 (Apr 19 2012) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 21131072 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Platelet Glycoprotein GPIIb-IIIa Complex
• Tyrosine
• Tirofiban

Topics

• Adult
• Aged
• Combined Modality Therapy (methods)
• Coronary Thrombosis (drug therapy, metabolism, surgery)
• Cross-Sectional Studies
• Female
• Humans
• Male
• Middle Aged
• Platelet Glycoprotein GPIIb-IIIa Complex (antagonists & inhibitors, metabolism)
• Prospective Studies
• Suction
• Tirofiban
• Treatment Outcome
• Tyrosine (analogs & derivatives, pharmacology, therapeutic use)