Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma.

Abstract

Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, Amijiol-7, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8β-hydroxypachydictyol A (5), Amijiol (6), Isodictyohemiacetal (7) and Dictyol C (8) from the Red Sea brown alga Dictyota dichotoma var. implexa. The structures and relative stereochemistry of the new diterpenoids were proposed on the basis of their spectral data. Compounds 3 and 9 have potent activity against DNA damage, cytotoxicity against WI-38, HepG2, and MCF-7 cell lines, and antioxidant using ABTS and erythrocytes hemolysis.

• Authors: Seif-Eldin N Ayyad, Mohamed S Makki, Nazeeha S Al-Kayal, Salim A Basaif, Kalid O El-Foty, Abdullah M Asiri, Walied M Alarif, Farid A Badria
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 46 Issue 1 Pg. 175-82 (Jan 2011) ISSN: 1768-3254 [Electronic] France
• PMID: 21130542 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antineoplastic Agents
• Antioxidants
• Benzothiazoles
• Diterpenes
• Sulfonic Acids
• 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology, toxicity)
• Antioxidants (chemistry, isolation & purification, pharmacology, toxicity)
• Benzothiazoles (pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Chlorocebus aethiops
• DNA Damage
• Diterpenes (chemistry, isolation & purification, pharmacology, toxicity)
• Erythrocytes (drug effects, immunology)
• Hemolysis (drug effects)
• Humans
• Phaeophyta (chemistry)
• Sulfonic Acids (pharmacology)
• Vero Cells