The effect of rotavirus immunization on rotavirus gastroenteritis hospitalization rates in military dependents.

Abstract

We conducted a retrospective review of all U.S. military dependents less than 5 years old hospitalized with rotavirus-associated gastroenteritis from July 2003 to June 2009. The two post-vaccine seasons showed a significant reduction of 62.4% (95% CI, 58.6-65.8, P<0.001) in rotavirus gastroenteritis hospitalization rate compared to the three pre-vaccine seasons. Infants less than 12 months old showed the greatest reduction in incidence at 75.3%. A substantial decrease was also seen in unvaccinated children as well. Vaccine efficacy against hospitalization was 86.0% (95% CI, 77.7-91.3) after just a single dose. The overwhelming majority of children hospitalized for rotavirus since the introduction of the vaccine (ranging from 91.8 to 100% per season) had not received any of the rotavirus vaccine series.

• Authors: Matthew D Eberly, Greg H Gorman, Matilda B Eide, Cara H Olsen, Michael Rajnik
• Journal: Vaccine (Vaccine) Vol. 29 Issue 4 Pg. 650-9 (Jan 17 2011) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 21129394 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Rotavirus Vaccines

Topics

• Child, Preschool
• Family Health
• Gastroenteritis (epidemiology, prevention & control)
• Hospitalization (statistics & numerical data)
• Humans
• Immunization (methods)
• Incidence
• Infant
• Infant, Newborn
• Military Personnel
• Retrospective Studies
• Rotavirus Infections (epidemiology, prevention & control)
• Rotavirus Vaccines (administration & dosage, immunology)
• United States (epidemiology)