Effects of safflower seed extract on arterial stiffness.

Safflower seed extract (SSE) contains characteristic polyphenols and serotonin derivatives (N-( p-coumaroyl) serotonin and N-feruloylserotonin), which are reported to inhibit oxidation of low-density lipoprotein (LDL), formation of atherosclerotic plaques, and improve arterial stiffness as assessed by pulse wave analysis in animal models. The effects of long-term supplementation with SSE on arterial stiffness in human subjects were evaluated. This doubleblind, placebo-controlled study was conducted in 77 males (35-65 years) and 15 postmenopausal females (55-65 years) with high-normal blood pressure or mild hypertension who were not undergoing treatment. Subjects received SSE (70 mg/day as serotonin derivatives) or placebo for 12 weeks, and pulse wave measurements, ie, second derivative of photoplethysmogram (SDPTG), augmentation index, and brachial-ankle pulse wave velocity (baPWV) were conducted at baseline, and at weeks 4, 8, and 12. Vascular age estimated by SDPTG aging index improved in the SSE-supplemented group when compared with the placebo group at four (P = 0.0368) and 12 weeks (P = 0.0927). The trend of augmentation index reduction (P = 0.072 versus baseline) was observed in the SSE-supplemented group, but reduction of baPWV by SSE supplementation was not observed. The SSE-supplemented group also showed a trend towards a lower malondialdehyde-modified-LDL autoantibody titer at 12 weeks from baseline. These results suggest long-term ingestion of SSE in humans could help to improve arterial stiffness.
AuthorsKatsuya Suzuki, Shigekazu Tsubaki, Masami Fujita, Naoto Koyama, Michio Takahashi, Kenji Takazawa
JournalVascular health and risk management (Vasc Health Risk Manag) Vol. 6 Pg. 1007-14 ( 2010) ISSN: 1178-2048 [Electronic] New Zealand
PMID21127697 (Publication Type: Controlled Clinical Trial, Journal Article)
Chemical References
  • Lipoproteins, LDL
  • Placebos
  • Plant Extracts
  • Safflower Oil
  • Adult
  • Aged
  • Ankle (blood supply)
  • Arteries (drug effects, physiopathology)
  • Blood Pressure (drug effects)
  • Carthamus tinctorius (chemistry)
  • Double-Blind Method
  • Female
  • Humans
  • Hypertension
  • Lipoproteins, LDL (blood, drug effects)
  • Male
  • Middle Aged
  • Placebos
  • Plant Extracts (pharmacology, therapeutic use)
  • Plaque, Atherosclerotic (prevention & control)
  • Postmenopause
  • Pulsatile Flow (drug effects)
  • Safflower Oil (pharmacology, therapeutic use)
  • Seeds (chemistry)
  • Treatment Outcome

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