Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury.

Abstract

More and more attention in the field of drug discovery has been focused on the neuroprotection of natural compounds from traditional medicinal herbs. Cerebral ischemia is a complex pathological process involving a series of mechanisms, and a framework for the development of neuroprotectants from traditional herb medicine is a promising treatment for cerebral ischemia. Natural compounds with the effects of anti-oxidation, anti-inflammation, calcium antagonization, anti-apoptosis, and neurofunctional regulation exhibit preventive or therapeutic effects on experimental ischemic brain injury. According to the pharmacological mechanisms underlying neuroprotection, we evaluated natural products from traditional medicinal herbs that exhibit protective effects on ischemic brain injury and characterized the promising targets.

• Authors: Peng-fei WU, Zui ZHANG, Fang WANG, Jian-guo CHEN
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 31 Issue 12 Pg. 1523-31 (Dec 2010) ISSN: 1745-7254 [Electronic] United States
• PMID: 21127495 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Neuroprotective Agents
• Plant Extracts

Topics

• Animals
• Brain Ischemia (drug therapy, prevention & control)
• Humans
• Medicine, Traditional
• Neuroprotective Agents (chemistry, therapeutic use)
• Phytotherapy
• Plant Extracts (chemistry, therapeutic use)
• Plants, Medicinal (chemistry)
• Reperfusion Injury (prevention & control)