Preventing erosion with novel agents.

Abstract

OBJECTIVES:

This in vitro study aimed to investigate the protective effect of four commercial novel agents against erosion.

METHODS:

Ninety human molars were distributed into 9 groups, and after incubation in human saliva for 2 h, a pellicle was formed. Subsequently, the specimens were submitted to demineralization (orange juice, pH 3.6, 3 min) and remineralization (paste slurry containing one of the tested novel agents, 3 min) cycles, two times per day, for 4 days. The tested agents were: (1) DenShield Tooth; active ingredient: 7.5% W/W NovaMin(®) (calcium sodium phosphosilicate); (2) Nanosensitive hca; active ingredient: 7.5% W/W NovaMin(®); (3) GC Tooth Mousse; active ingredient: 10% Recaldent™ (CPP-ACP); (4) GC MI Paste Plus; active ingredients: 10% Recaldent™, 900 ppm fluoride. Two experimental procedures were performed: in procedure 1, the tested agents were applied prior to the erosive attack, and in procedure 2 after the erosive attack. A control group receiving no prophylactic treatment was included. Surface nanohardness (SNH) of enamel specimens was measured after pellicle formation and after completion of daily cyclic treatment.

RESULTS:

SNH significantly decreased at the end of the experiment for all groups (p<0.05). In both procedures, there was no statistically significant difference between the control group and those treated with paste slurries (p>0.05). In addition, the changes in SNH (ΔSNH=SNHbaseline-SNHfinal) did not show statistically significant difference between both procedures (p>0.05).

CONCLUSION:

Tooth erosion cannot be prevented or repaired by these novel agents, regardless of fluoride content.

• Authors: X Wang, B Megert, E Hellwig, K W Neuhaus, A Lussi
• Journal: Journal of dentistry (J Dent) Vol. 39 Issue 2 Pg. 163-70 (Feb 2011) ISSN: 1879-176X [Electronic] England
• PMID: 21126556 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Caseins
• NovaMin
• Pharmaceutical Preparations, Dental
• Saliva, Artificial
• casein phosphopeptide-amorphous calcium phosphate nanocomplex
• Fluorides

Topics

• Beverages (adverse effects)
• Caseins (administration & dosage, therapeutic use)
• Citrus
• Dental Enamel (drug effects, ultrastructure)
• Dental Pellicle (drug effects, ultrastructure)
• Fluorides (administration & dosage, therapeutic use)
• Fruit
• Glass
• Hardness
• Humans
• Hydrogen-Ion Concentration
• Materials Testing
• Microscopy, Electron, Scanning
• Pharmaceutical Preparations, Dental (administration & dosage, therapeutic use)
• Saliva, Artificial
• Temperature
• Time Factors
• Tooth Erosion (pathology, prevention & control)
• Tooth Remineralization (methods)