Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy.

Abstract

OBJECTIVES:

To investigate the association of plasma levels of methylglyoxal (MG) and markers of inflammation/endothelial dysfunction with diabetic nephropathy (DN).

DESIGN AND METHODS:

Plasma levels of MG, cytokines, and adhesion molecules were measured in type 2 diabetic patients (T2DM), T2DM patients with DN, and the controls.

RESULTS:

Plasma MG levels in DN were significantly higher than those in T2DM and the controls (312 ± 135 vs. 212 ± 73 and 312 ± 135 vs. 147 ± 78 nmol/L, respectively, P<0.001). The plasma levels of MG were positively correlated with the fasting glucose, HbA1c, and urinary albumin/creatinine ratio (r=0.754, P<0.05). Plasma levels of IL-6, TNF-α, and adhesion molecules were markedly increased in DN compared to T2DM patients and the controls.

CONCLUSIONS:

Increased plasma levels of MG, cytokines, and adhesion molecules are associated with DN. These markers may be useful in predicting the development of DN.

• Authors: Jianxin Lu, Edward Randell, Yingchun Han, Khosrow Adeli, John Krahn, Qing H Meng
• Journal: Clinical biochemistry (Clin Biochem) Vol. 44 Issue 4 Pg. 307-11 (Mar 2011) ISSN: 1873-2933 [Electronic] United States
• PMID: 21126514 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Chemical References

• Albumins
• Biomarkers
• Blood Glucose
• Cell Adhesion Molecules
• Glycated Hemoglobin A
• Interleukin-6
• Tumor Necrosis Factor-alpha
• hemoglobin A1c protein, human
• Pyruvaldehyde
• Creatinine

Topics

• Albumins (analysis)
• Biomarkers (analysis)
• Blood Glucose (analysis)
• Case-Control Studies
• Cell Adhesion Molecules (blood)
• Creatinine (urine)
• Diabetic Nephropathies (blood, physiopathology)
• Endothelium, Vascular (metabolism, physiopathology)
• Female
• Glycated Hemoglobin (analysis)
• Humans
• Inflammation (blood)
• Interleukin-6 (blood)
• Male
• Middle Aged
• Plasma (chemistry)
• Pyruvaldehyde (blood)
• Tumor Necrosis Factor-alpha (blood)