AL amyloidosis in a young adult: remission with autologous stem cell transplantation.

Abstract

Autologous stem cell transplant is one of the therapies employed in the treatment of primary amyloidosis or AL. The authors report on a 46-year-old patient with bilateral periorbital hematomas, macroglossia who presented, during the investigation, IgG-Kappa paraprotein in serum. The diagnosis of primary amyloidosis or AL was confirmed and the treatment proposed consisted of high-dose melphalan as conditioning regimen before autologous stem cell transplant, which determined complete remission of the disease, along with the disappearance of clinical signs and absence of the monoclonal component.

• Authors: Ricardo Prado Golmia, Isabel Clapis Bello, Eliane Rosseto, João Carlos Campos Guerra, Cristóvão Mangueira, Morton Aaron Scheinberg
• Journal: Revista brasileira de reumatologia (Rev Bras Reumatol) 2010 Sep-Oct Vol. 50 Issue 5 Pg. 603-8 ISSN: 1809-4570 [Electronic] Brazil
• PMID: 21125195 (Publication Type: Case Reports, Journal Article)

Topics

• Amyloidosis (surgery)
• Humans
• Immunoglobulin Light-chain Amyloidosis
• Male
• Middle Aged
• Remission Induction
• Stem Cell Transplantation