Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents.

Abstract	Efforts to develop novel, interferon-sparing therapies for treatment of chronic hepatitis C (HCV) infection are contingent on the ability of combination therapies consisting of direct antiviral inhibitors to achieve a sustained virologic response. This work demonstrates a proof of concept that coadministration of the nucleoside analogue MK-0608 with the protease inhibitor MK-7009, both of which produced robust viral load declines as monotherapy, to an HCV-infected chimpanzee can achieve a cure of infection.
Authors	David B Olsen, Mary-Ellen Davies, Larry Handt, Kenneth Koeplinger, Nanyan Rena Zhang, Steven W Ludmerer, Donald Graham, Nigel Liverton, Malcolm MacCoss, Daria Hazuda, Steven S Carroll
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 55 Issue 2 Pg. 937-9 (Feb 2011) ISSN: 1098-6596 [Electronic] United States
PMID	21115793 (Publication Type: Journal Article)
Chemical References	Antiviral Agents Cyclopropanes Indoles Isoindoles Lactams, Macrocyclic NS3 protein, hepatitis C virus Protease Inhibitors Sulfonamides Viral Nonstructural Proteins Proline vaniprevir Leucine Tubercidin 7-deaza-2'-C-methyladenosine
Topics	Animals Antiviral Agents (administration & dosage, pharmacology, therapeutic use) Cyclopropanes Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Hepacivirus (drug effects, enzymology, physiology) Hepatitis C, Chronic (drug therapy, virology) Indoles (administration & dosage, pharmacology, therapeutic use) Isoindoles Lactams, Macrocyclic Leucine (analogs & derivatives) Pan troglodytes (virology) Proline (analogs & derivatives) Protease Inhibitors (administration & dosage, pharmacology, therapeutic use) Sulfonamides Treatment Outcome Tubercidin (administration & dosage, analogs & derivatives, pharmacology, therapeutic use) Viral Load (drug effects) Viral Nonstructural Proteins (antagonists & inhibitors)

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