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SIRT3 in calorie restriction: can you hear me now?

Abstract
Caloric restriction decreases oxidative damage and extends life span in many organisms. Someya et al. (2010) show that the sirtuin SIRT3 mediates the protective effects of caloric restriction on age-related hearing loss by promoting the mitochondrial antioxidant system through the regulation of isocitrate dehydrogenase 2 (Idh2).
AuthorsCarlos Sebastian, Raul Mostoslavsky
JournalCell (Cell) Vol. 143 Issue 5 Pg. 667-8 (Nov 24 2010) ISSN: 1097-4172 [Electronic] United States
PMID21111225 (Publication Type: Comment, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 Elsevier Inc. All rights reserved.

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