Abstract | BACKGROUND: MATERIAL AND METHODS: A mouse melanoma model was used to investigate the efficacy of gold-1a in inhibiting angiogenesis, tumor growth and prolonging the survival of the tumor-bearing animals. The model was established by inoculation of 2 × 10(5) B16-F1 mouse melanoma cells into the right back flanks of the mice by subcutaneous inoculation. When the tumors grew to 0.2-0.4 cm in diameters, the mice were treated with gold-1a, solvent control or dacarbazine ( DTIC) for comparison. Tumor sizes and animal survivals were monitored throughout the experiment. Tumor tissues were collected and immunohistochemically stained with CD31 antibodies for evaluation of intra-tumoral microvessel density (iMVD). RESULTS AND CONCLUSION: Gold-1a significantly prolonged the survivals, reduced angiogenesis and tumor growth rates of melanoma-bearing mice. The compound induced necrosis and apoptosis in the mouse melanoma tissues. Gold-1a also downregulated the expression of genes playing roles in angiogenesis. Gold-1a may potentially be used to treat melanoma in patients.
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Authors | Ching Tung Lum, Longfei Huo, Raymond Wai-Yin Sun, Ming Li, Hsiang Fu Kung, Chi-Ming Che, Marie C M Lin |
Journal | Acta oncologica (Stockholm, Sweden)
(Acta Oncol)
Vol. 50
Issue 5
Pg. 719-26
(Jun 2011)
ISSN: 1651-226X [Electronic] England |
PMID | 21110776
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Metalloporphyrins
- gold (III) porphyrin 1a
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology, therapeutic use)
- Carcinoma
(drug therapy, mortality)
- Cell Line, Tumor
- Cells, Cultured
- Colonic Neoplasms
(drug therapy, mortality)
- Female
- Melanoma, Experimental
(drug therapy, mortality)
- Metalloporphyrins
(pharmacology, therapeutic use)
- Mice
- Mice, Inbred C57BL
- Neoplasm Transplantation
- Neovascularization, Pathologic
(prevention & control)
- Survival
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