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Robust electrochemical system for screening single nucleotide polymorphisms.

Abstract
A highly sensitive and selective electrochemical DNA signaling scheme, which identifies the point mutation existing in target DNA sequence, is developed based on the combination of label-free hairpin probe (HP)/DNA endonuclease with zirconia (ZrO(2)) nanoparticle film, representing a promising screening platform for the accurate diagnosis of infections and genetic diseases as well as for environmental and forensic applications.
AuthorsRong Hu, Zai-Sheng Wu, Songbai Zhang, Guo-Li Shen, Ruqin Yu
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 47 Issue 4 Pg. 1294-6 (Jan 28 2011) ISSN: 1364-548X [Electronic] England
PMID21103482 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA Probes
  • DNA
  • Zirconium
  • zirconium oxide
Topics
  • DNA (analysis)
  • DNA Probes (chemistry)
  • Electrochemical Techniques (methods)
  • Inverted Repeat Sequences
  • Metal Nanoparticles (chemistry, ultrastructure)
  • Polymorphism, Single Nucleotide
  • Zirconium (chemistry)

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