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Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5.

Abstract
It has previously been reported that shedding of the PTPκ ectodomain drives enhanced motility of colon cancer cells. Herein, we provide mechanism underlying the regulation of PTPκ shedding by galectin-3 binding protein. PTPκ was inarguably scissored by the processed form of proprotein convertase 5 (subtilisin/kexin type 5), and galectin-3 binding protein which is over-produced in colon cancer cells and tissues contributed to increased cancer cell motility by acting as a negative regulator of galectin-3 at the cell surface. The high expression ratio of galectin-3 binding protein to galectin-3 was clinically correlated to lymphatic invasion. These results suggest that galectin-3 binding protein may be a potential therapeutic target for treatment of, at least, colon cancer patients with high expression of galectin-3 binding protein.
AuthorsYong-Sam Kim, Jee-Ae Jung, Hyun-Jung Kim, Yeong Hee Ahn, Jong Shin Yoo, Sejeong Oh, Changhee Cho, Hyang-Sook Yoo, Jeong-Heon Ko
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 404 Issue 1 Pg. 96-102 (Jan 07 2011) ISSN: 1090-2104 [Electronic] United States
PMID21094132 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 Elsevier Inc. All rights reserved.
Chemical References
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Carrier Proteins
  • Galectin 3
  • Glycoproteins
  • LGALS3BP protein, human
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2
  • Proprotein Convertase 5
Topics
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Carrier Proteins (metabolism)
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Colonic Neoplasms (metabolism, pathology)
  • Galectin 3 (metabolism)
  • Glycoproteins (metabolism)
  • Humans
  • Proprotein Convertase 5 (metabolism)
  • Protein Structure, Tertiary
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2 (metabolism)
  • Tumor Cells, Cultured

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