Abstract | OBJECTIVE: to analyze the relationship between the expression of SM22α and the lymph node (LN) metastasis of breast cancer and to investigate its molecular mechanisms. METHODS: RESULTS: the expression level of SM22α mRNA in breast cancer was significantly lower than that in breast fibroadenoma or adjacent normal breast tissue (5.1% ± 2.4% vs 15.1% ± 5.3% vs 30.1% ± 5.1%, P < 0.01). The protein and mRNA expression level of SM22α in breast cancer samples with LN metastasis were significant lower than those of breast cancer without LN metastasis (6.2% ± 3.1% vs 10.1% ± 4.1%, P < 0.01). Both the expression and activity of MMP2 and MMP9 in breast cancer samples with LN metastasis were significant higher than those without LN metastasis (P < 0.01). A strong negative correlation was found between SM22α protein level and MMP2 activity (r = -0.848; n = 27; P < 0.01) or MMP9 activity (r = -0.916; n = 27; P < 0.01) in breast cancer tissue. CONCLUSION:
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Authors | Zhen-feng MA, Nai-peng CUI, Jian-hong SHI, Huai-ying WANG, Shao-hui SHI, Ming WEN, Zhong LI |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 90
Issue 36
Pg. 2545-8
(Sep 28 2010)
ISSN: 0376-2491 [Print] China |
PMID | 21092460
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Microfilament Proteins
- Muscle Proteins
- RNA, Messenger
- transgelin
- MMP2 protein, human
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
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Topics |
- Breast Neoplasms
(metabolism, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
(pathology)
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase 9
(metabolism)
- Microfilament Proteins
(metabolism)
- Muscle Proteins
(metabolism)
- Prognosis
- RNA, Messenger
(genetics)
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