HLA-DR6 association confers increased resistance to T. rubrum onychomycosis in Mexican Mestizos.

Abstract

BACKGROUND:

Onychomycosis is multifactorial in origin. Studies have suggested an autosomal dominant pattern of inheritance and human leukocyte antigen DR4 (HLA-DR4) has been shown to protect against onychomycosis in an Ashkenazi Jewish population.

AIM:

This study investigates HLA class II association in a Mexican Mestizo population with Trichophyton rubrum onychomycosis.

METHODS:

This was a prospective case-control study. Mexican Mestizos with a clinical diagnosis of onychomycosis and culture positive for T. rubrum were recruited, together with age- and sex-matched controls. First-degree relatives were also investigated for onychomycosis. Case-control samples were HLA typed by polymerase chain reaction sequence-specific primer based analysis.

RESULTS:

Twenty-one cases and 42 controls were recruited with a mean age of 40 years (range: 18-58 years). HLA-DR6 was found in seven (33%) cases and 19 (45%) controls [P < 0.023, odds ratio (OR) = 0.088, 95% confidence interval (CI): 0.01-0.71]. Six (29%) cases and three (7%) controls had an affected child (P < 0.043, OR = 9.15, 95% CI: 1.07-78.31), and 13 (62%) cases and 12 (29%) controls had an affected first-degree relative (P < 0.02, OR = 4.0, 95% CI: 1.1-14.3).

CONCLUSIONS:

These results suggest that HLA-DR6 confers protection against the development of onychomycosis in a Mexican Mestizo population. Having an affected first-degree relative significantly increases the risk of onychomycosis, suggesting genetic susceptibility.

• Authors: Daniel Asz-Sigall, Lirio López-García, María Elisa Vega-Memije, Rosa María Lacy-Niebla, Cristina García-Corona, Claudia Ramírez-Rentería, Julio Granados, Antonio Villa, Mahreen Ameen, Roberto Arenas
• Journal: International journal of dermatology (Int J Dermatol) Vol. 49 Issue 12 Pg. 1406-9 (Dec 2010) ISSN: 1365-4632 [Electronic] England
• PMID: 21091674 (Publication Type: Journal Article)
• Copyright: © 2010 The International Society of Dermatology.

Chemical References

• HLA-DR6 Antigen

Topics

• Adolescent
• Adult
• Alleles
• Black People (genetics)
• Case-Control Studies
• Female
• Genetic Predisposition to Disease
• Genotype
• HLA-DR6 Antigen (genetics)
• Humans
• Indians, South American (genetics)
• Male
• Mexico (epidemiology)
• Middle Aged
• Onychomycosis (ethnology, genetics, microbiology)
• Prospective Studies
• Trichophyton (isolation & purification)
• White People (genetics)
• Young Adult