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Serum carbonic anhydrase III and myoglobin concentrations in acute myocardial infarction.

Abstract
Serum concentrations of myoglobin (S-Myo) and carbonic anhydrase III (S-CA III; EC 4.2.1.1), a skeletal muscle-specific protein, were measured by RIA in 26 patients with acute myocardial infarction, 14 patients with neuromuscular diseases, and six healthy subjects before and after physical exercise. S-Myo was increased in infarct patients, whereas S-CA III was not altered. In patients with neuromuscular diseases and in healthy subjects after physical exercise, both S-Myo and S-CA III were significantly increased. S-CA III and S-Myo also showed identical peak times, 2 h postexercise. The S-Myo/S-CA III ratio was always higher in infarct patients than in the other groups. Thus, the combination of S-CA III and S-Myo determinations is useful to differentiate whether serum myoglobin is originating from myocardium or from skeletal muscle.
AuthorsH K Väänänen, H Syrjälä, P Rahkila, J Vuori, L M Melamies, V Myllylä, T E Takala
JournalClinical chemistry (Clin Chem) Vol. 36 Issue 4 Pg. 635-8 (Apr 1990) ISSN: 0009-9147 [Print] England
PMID2108824 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Myoglobin
  • Creatine Kinase
  • Carbonic Anhydrases
Topics
  • Adult
  • Carbonic Anhydrases (blood)
  • Creatine Kinase (blood)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle, Smooth (metabolism)
  • Muscles (metabolism)
  • Myocardial Infarction (blood, enzymology)
  • Myoglobin (blood)
  • Neuromuscular Diseases (enzymology)
  • Radioimmunoassay

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