Abstract |
Serum concentrations of myoglobin (S-Myo) and carbonic anhydrase III (S-CA III; EC 4.2.1.1), a skeletal muscle-specific protein, were measured by RIA in 26 patients with acute myocardial infarction, 14 patients with neuromuscular diseases, and six healthy subjects before and after physical exercise. S-Myo was increased in infarct patients, whereas S-CA III was not altered. In patients with neuromuscular diseases and in healthy subjects after physical exercise, both S-Myo and S-CA III were significantly increased. S-CA III and S-Myo also showed identical peak times, 2 h postexercise. The S-Myo/S-CA III ratio was always higher in infarct patients than in the other groups. Thus, the combination of S-CA III and S-Myo determinations is useful to differentiate whether serum myoglobin is originating from myocardium or from skeletal muscle.
|
Authors | H K Väänänen, H Syrjälä, P Rahkila, J Vuori, L M Melamies, V Myllylä, T E Takala |
Journal | Clinical chemistry
(Clin Chem)
Vol. 36
Issue 4
Pg. 635-8
(Apr 1990)
ISSN: 0009-9147 [Print] England |
PMID | 2108824
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Myoglobin
- Creatine Kinase
- Carbonic Anhydrases
|
Topics |
- Adult
- Carbonic Anhydrases
(blood)
- Creatine Kinase
(blood)
- Female
- Humans
- Male
- Middle Aged
- Muscle, Smooth
(metabolism)
- Muscles
(metabolism)
- Myocardial Infarction
(blood, enzymology)
- Myoglobin
(blood)
- Neuromuscular Diseases
(enzymology)
- Radioimmunoassay
|