Perioperative antibiotic prophylaxis: improved compliance and impact on infection rates.

Abstract

The aims of this study were to determine adherence to the perioperative antibiotic prophylaxis (PAP) protocol used at a large Italian teaching hospital during a 6-year period, to assess the variables associated with inappropriate administration, and to measure the impact on surgical site infection (SSI) rates. There were 28 621 patients surveyed of which 74·6% received PAP. An improvement in adherence to the PAP protocol was registered for 58·8% of patients. Significant risk factors were an American Society of Anesthesiologists (ASA) score ≥ 2 [odds ratios (OR) from 1·28 (95% confidence interval (CI) 1·19-1·37) to 1·87 (95% CI 1·43-2·44)], prolonged duration of surgery (OR 1·68, 95% CI 1·56-1·82) and urgent surgery (OR 2·16, 95% CI 1·96-2·37). During the study period, a significant reduction in SSIs rates was detected. We concluded that the global reduction of inadequate PAP administration signifies the efficacy of a multidisciplinary quality improvement initiative on antimicrobial utilization, and this is supported by the observed reduction of the SSI rate.

• Authors: E Prospero, P Barbadoro, A Marigliano, E Martini, M M D'Errico
• Journal: Epidemiology and infection (Epidemiol Infect) Vol. 139 Issue 9 Pg. 1326-31 (Sep 2011) ISSN: 1469-4409 [Electronic] England
• PMID: 21087536 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Anti-Bacterial Agents (therapeutic use)
• Antibiotic Prophylaxis
• Female
• Health Knowledge, Attitudes, Practice
• Humans
• Infection Control
• Male
• Perioperative Care
• Surgical Wound Infection (drug therapy, prevention & control)