Apolipoprotein A-I and apolipoprotein SAA half-lives during acute inflammation and amyloidogenesis.

Abstract

The half-lives of two apolipoproteins of mouse high-density lipoproteins, apo A-I and apo SAA, were determined in normal animals and compared with those having an inflammatory condition, or inflammation leading to AA amyloid deposition. The apo A-I half-life was considerably shorter in animals with inflammation and in those that were preamyloidotic, than in controls (t1/2 of 3-3.5 h vs. 10-12 h). The average loss of apo A-I in controls over the first 10 h was 31.1 micrograms/ml per h, while that in inflamed animals was 58.7 micrograms/ml per h a 2-fold increase in apo A-I clearance. The apo SAA half-life was similar in all groups of animals and was of the order of 1.5 h. The concentration of apo SAA during inflammation is however considerably higher (500-1000-fold) than in controls, which implies a much greater clearance rate during inflammation and involving a process which is apparently not saturable. In addition to hypertriglyceridemia and Tangier's disease, ordinary acute inflammation can now be added to those pathological conditions which lead to a significant decrease in apo A-I half-life.

• Authors: C Tape, R Kisilevsky
• Journal: Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1043 Issue 3 Pg. 295-300 (Apr 17 1990) ISSN: 0006-3002 [Print] Netherlands
• PMID: 2108727 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid
• Apolipoprotein A-I
• Apolipoproteins A
• Lipoproteins, HDL
• Serum Amyloid A Protein

Topics

• Amyloid (biosynthesis)
• Amyloidosis (metabolism)
• Animals
• Apolipoprotein A-I
• Apolipoproteins A (metabolism)
• Inflammation (metabolism)
• Lipoproteins, HDL (metabolism)
• Metabolic Clearance Rate
• Mice
• Mice, Inbred CBA
• Serum Amyloid A Protein (metabolism)