Treatment of experimental listeriosis by CI 934, a new quinolone.

Abstract

CI 934, a new quinolone, is only marginally more active in vitro against Listeria monocytogenes and other Listeria spp. than ciprofloxacin. A bactericidal effect is seen only after several hours of incubation. However, mice infected with a virulent strain of L. monocytogenes were protected by parenteral treatment with CI 934. With a dosage of 2 x 2 mg CI 934 per day for three days almost complete remission could be achieved. These results are somewhat better than those obtained in previous experiments with other antibiotics.

• Authors: H Hof
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 25 Issue 1 Pg. 121-6 (Jan 1990) ISSN: 0305-7453 [Print] England
• PMID: 2108112 (Publication Type: Journal Article)

Chemical References

• 4-Quinolones
• Anti-Infective Agents
• Fluoroquinolones
• CI 934

Topics

• 4-Quinolones
• Anti-Infective Agents (therapeutic use)
• Cell Division (drug effects)
• Fluoroquinolones
• Listeria monocytogenes (physiology)
• Listeriosis (drug therapy)
• Microbial Sensitivity Tests