Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1.

Abstract

The prognostic and/or predictive value of the cancer biomarkers, urokinase-type plasminogen activator (uPA) and its inhibitor (plasminogen activator inhibitor [PAI]-1), determined by ELISA in tumor-tissue extracts, was demonstrated for several cancer types in numerous clinically relevant retrospective or prospective studies, including a multicenter breast cancer therapy trial (Chemo-N0). Consequently, for the first time ever for any cancer biomarker for breast cancer, uPA and PAI-1 have reached the highest level of evidence, level-of-evidence-1. At present, two other breast cancer therapy trials, NNBC-3 and Plan B, also incorporating uPA and PAI-1 as treatment-assignment tools are in effect. Furthermore, small synthetic molecules targeting uPA are currently in Phase II clinical trials in patients afflicted with advanced cancer of the ovary, breast or pancreas.

• Authors: Manfred Schmitt, Karin Mengele, Rudolf Napieralski, Viktor Magdolen, Ute Reuning, Apostolos Gkazepis, Fred Sweep, Nils Brünner, John Foekens, Nadia Harbeck
• Journal: Expert review of molecular diagnostics (Expert Rev Mol Diagn) Vol. 10 Issue 8 Pg. 1051-67 (Nov 2010) ISSN: 1744-8352 [Electronic] England
• PMID: 21080821 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers, Tumor
• Oligonucleotides, Antisense
• Plasminogen Activator Inhibitor 1
• RNA, Small Interfering
• Serine Proteinase Inhibitors
• Urokinase-Type Plasminogen Activator

Topics

• Biomarkers, Tumor (analysis)
• Breast Neoplasms (chemistry, diagnosis, drug therapy)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Neoplasms (chemistry, diagnosis, drug therapy)
• Oligonucleotides, Antisense (therapeutic use)
• Plasminogen Activator Inhibitor 1 (analysis, genetics)
• Prognosis
• RNA, Small Interfering (therapeutic use)
• Retrospective Studies
• Serine Proteinase Inhibitors (therapeutic use)
• Urokinase-Type Plasminogen Activator (analysis, genetics)