Fanconi syndrome in a patient with β-thalassemia major after using deferasirox for 27 months.

Abstract

BACKGROUND:

Deferasirox (DFRA) is a new approved oral iron chelator. Its advantages are that it is convenient and better tolerated and adhered to due to "once-daily" oral dosage. However, its use in the field is limited and it is yet to be subjected to postmarketing surveillance.

CASE REPORT:

A 18.75-year-old male with β-thalassemia major received oral DFRA therapy due to transfusional iron overload for 27 months. He had received iron chelation therapy with deferoxamine injection together with oral deferiprone. However, his compliance was poor (very high routine serum ferritin level, ranging from 1059 to 6030 ng/mL). After 25 months of DFRA therapy, the serum ferritin level declined from 4097 to 1343 ng/mL. He experienced five hospital admissions including coma, Fanconi syndrome, hepatic dysfunction, and thrombocytopenia after using DFRA as oral iron chelator. After we discontinued DFRA, he recovered fully without hepatic dysfunction, thrombocytopenia, proteinuria, glucosuria, and hypophosphatemia.

CONCLUSIONS:

Our case illustrates the potential risks of DFRA-induced renal toxicity, hepatic dysfunction, and thrombocytopenia. Meticulous monitoring of kidney, liver, and hematopoietic function is mandatory for patients undergoing treatment with DFRA. Further investigation of the potential risk and adverse effects of long-term DFRA use is necessary.

• Authors: Hsin-Yi Wei, Chao-Ping Yang, Chi-Hui Cheng, Fu-Sung Lo
• Journal: Transfusion (Transfusion) Vol. 51 Issue 5 Pg. 949-54 (May 2011) ISSN: 1537-2995 [Electronic] United States
• PMID: 21077910 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2010 American Association of Blood Banks.

Chemical References

• Benzoates
• Iron Chelating Agents
• Triazoles
• Deferasirox

Topics

• Adolescent
• Benzoates (administration & dosage, adverse effects)
• Deferasirox
• Fanconi Syndrome (chemically induced)
• Hospitalization
• Humans
• Iron Chelating Agents (administration & dosage, adverse effects)
• Iron Overload (drug therapy, etiology)
• Kidney (drug effects)
• Male
• Transfusion Reaction
• Triazoles (administration & dosage, adverse effects)
• beta-Thalassemia (therapy)