Abstract |
Recently it was demonstrated that Shigella dysenteriae type 1, a cause of severe dysentery epidemics, gained its O-specific polysaccharide (O-SP) from Escherichia coli O148. The O-SPs of these bacteria differ only by a galactose residue in the repeat unit of S. dysenteriae type 1 in place of a glucose residue in E. coli O148. Herein, we analyzed the core structure and its linkage to the O-SP in E. coli O148 LPS. Both were found to be identical to those of S. dysenteriae type 1 structures, further supporting the relatedness of these two bacteria. The following structure of the core with one repeat unit of the O-SP has been assigned (all have d-configuration except l-Rha):
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Authors | Joanna Kubler-Kielb, Wen-Tzu Lai, Rachel Schneerson, Evgeny Vinogradov |
Journal | Carbohydrate research
(Carbohydr Res)
Vol. 346
Issue 1
Pg. 150-2
(Jan 03 2011)
ISSN: 1873-426X [Electronic] Netherlands |
PMID | 21074753
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Copyright | 2010 Elsevier Ltd. All rights reserved. |
Chemical References |
- Lipopolysaccharides
- O Antigens
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Topics |
- Carbohydrate Sequence
- Escherichia coli
(chemistry)
- Lipopolysaccharides
(chemistry)
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Molecular Sequence Data
- O Antigens
(chemistry)
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