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The structure of the Escherichia coli O148 lipopolysaccharide core region and its linkage to the O-specific polysaccharide.

Abstract
Recently it was demonstrated that Shigella dysenteriae type 1, a cause of severe dysentery epidemics, gained its O-specific polysaccharide (O-SP) from Escherichia coli O148. The O-SPs of these bacteria differ only by a galactose residue in the repeat unit of S. dysenteriae type 1 in place of a glucose residue in E. coli O148. Herein, we analyzed the core structure and its linkage to the O-SP in E. coli O148 LPS. Both were found to be identical to those of S. dysenteriae type 1 structures, further supporting the relatedness of these two bacteria. The following structure of the core with one repeat unit of the O-SP has been assigned (all have d-configuration except l-Rha):
AuthorsJoanna Kubler-Kielb, Wen-Tzu Lai, Rachel Schneerson, Evgeny Vinogradov
JournalCarbohydrate research (Carbohydr Res) Vol. 346 Issue 1 Pg. 150-2 (Jan 03 2011) ISSN: 1873-426X [Electronic] Netherlands
PMID21074753 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
Copyright2010 Elsevier Ltd. All rights reserved.
Chemical References
  • Lipopolysaccharides
  • O Antigens
Topics
  • Carbohydrate Sequence
  • Escherichia coli (chemistry)
  • Lipopolysaccharides (chemistry)
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Sequence Data
  • O Antigens (chemistry)

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