SUN N8075, a novel radical scavenger, protects against retinal cell death in mice.

Abstract

In this study, we examined the effect of SUN N8075, a radical scavenger with neuroprotective properties, on murine retinal damage induced by intravitreous injection of N-methyl-d-aspartate (NMDA) or high-intraocular pressure (IOP). In both models, systemic administration of SUN N8075 decreased the cell loss in the ganglion cell layer (GCL) after retinal damage occurred. Moreover, SUN N8075 reduced the number of apoptotic cells and the expression of an oxidative stress marker in GCL in the NMDA model. These findings suggest that SUN N8075 has a neuroprotective effect against retinal damage, presumably via the radical scavenging effect.

• Authors: Mai Akane, Masamitsu Shimazawa, Yuta Inokuchi, Kazuhiro Tsuruma, Hideaki Hara
• Journal: Neuroscience letters (Neurosci Lett) Vol. 488 Issue 1 Pg. 87-91 (Jan 13 2011) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 21073924 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Aniline Compounds
• Neuroprotective Agents
• Piperazines
• SUN N8075
• N-Methylaspartate
• Dizocilpine Maleate
• 8-Hydroxy-2'-Deoxyguanosine
• Deoxyguanosine

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• Aniline Compounds (therapeutic use)
• Animals
• Cell Death (drug effects)
• Deoxyguanosine (analogs & derivatives, metabolism)
• Disease Models, Animal
• Dizocilpine Maleate (therapeutic use)
• In Situ Nick-End Labeling (methods)
• Mice
• N-Methylaspartate (toxicity)
• Neurons (drug effects)
• Neuroprotective Agents (therapeutic use)
• Ocular Hypertension (complications)
• Piperazines (therapeutic use)
• Retina (drug effects, pathology)
• Retinal Diseases (drug therapy, etiology, pathology)
• Time Factors