Abstract | BACKGROUND: MATERIALS: RESULTS: Three hundred and ten patients were enrolled and 92 (OAB-M-F), 95 (OAC-P), and 98 (OAB-C-F) completed the study. The intention-to-treat eradication rates were 78.5% (95% CI = 69-85), 81.1% (95% CI = 73-88), and 82% (95% CI = 74-89), and per-protocol eradication rates were 91.3% (95% CI = 83-96), 90.4% (95% CI = 82-95), and 88.7% (95% CI = 81-94), for group OAB-M-F, OAC-P, and OAB-C-F, respectively. Eradication rate differences did not reach statistical significance. The most common adverse event, bad taste, occurred in all groups, but more frequently in groups OAC-P (34%) and OAB-C-F (32%), than OAB-M-F (14%) (p < .05). Adverse symptoms score were 0.88 ± 2.05 in group OAB-M-F, 1.15 ± 1.40 in group OAC-P, and 1.87 ± 1.62 in group OAB-C-F. CONCLUSION:
Furazolidone can replace clarithromycin in H. pylori eradication regimens because of lack of development of resistance and very low cost.
|
Authors | Saghi Riahizadeh, Reza Malekzadeh, Shahram Agah, Nasrin Zendehdel, Rasoul Sotoudehmanesh, Naser Ebrahimi-Dariani, Akram Pourshams, Homayoon Vahedi, Javad Mikaeli, Morteza Khatibian, Sadegh Massarrat |
Journal | Helicobacter
(Helicobacter)
Vol. 15
Issue 6
Pg. 497-504
(Dec 2010)
ISSN: 1523-5378 [Electronic] England |
PMID | 21073605
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Copyright | © 2010 Blackwell Publishing Ltd. |
Chemical References |
- Anti-Bacterial Agents
- Metronidazole
- Furazolidone
- Clarithromycin
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(administration & dosage, adverse effects)
- Clarithromycin
(administration & dosage, adverse effects)
- Double-Blind Method
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Furazolidone
(administration & dosage, adverse effects)
- Helicobacter Infections
(drug therapy, microbiology)
- Helicobacter pylori
(drug effects, physiology)
- Humans
- Male
- Metronidazole
(administration & dosage, adverse effects)
- Middle Aged
- Peptic Ulcer
(drug therapy, microbiology)
- Young Adult
|