Abstract | PURPOSE: PATIENTS AND METHODS: Skin color (L*, a*, and b* values) and moisture analyses were performed for both breasts (before, after, 1 month, 6 months, and 1 year after radiotherapy) to examine irradiated and non-irradiated skin divided into four quadrants in 118 patients. These patients underwent breast conservative surgery followed by 50 Gy/25 fractions (median) of radiotherapy with or without boost irradiation (10 Gy/5 fractions). RESULTS: L*, a*, and moisture values were changed by irradiation and maximized at completion or 1 month after radiotherapy. One year after radiotherapy, the skin color had returned to the range observed prior to radiotherapy. However, moisture did not return to previous values even 1 year after treatment. The lateral upper side (quadrant C) showed greater changes than other quadrants in the L* value (darker) at the end of radiotherapy. The Common Toxicity Criteria version 3 scores were found to correlate well with a* and L* values at the completion and 1 month after radiotherapy. Boost radiotherapy intensified reddish and darker color changes at the completion of radiotherapy, while chemotherapy did not intensify the skin reaction caused by radiotherapy. CONCLUSION: Moisture impairment as a result of irradiation lasts longer than color alterations. Objective assessments are useful for analyzing radiation dermatitis.
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Authors | Ken Yoshida, Hideya Yamazaki, Tadashi Takenaka, Eiichi Tanaka, Tadayuki Kotsuma, Yuka Fujita, Norikazu Masuda, Keiko Kuriyama, Mineo Yoshida, Tsunehiko Nishimura |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 186
Issue 11
Pg. 621-9
(Nov 2010)
ISSN: 1439-099X [Electronic] Germany |
PMID | 21072624
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Breast Neoplasms
(drug therapy, pathology, radiotherapy, surgery)
- Carcinoma, Ductal, Breast
(drug therapy, pathology, radiotherapy, surgery)
- Carcinoma, Intraductal, Noninfiltrating
(drug therapy, pathology, radiotherapy, surgery)
- Chemotherapy, Adjuvant
- Combined Modality Therapy
- Dose Fractionation, Radiation
- Female
- Follow-Up Studies
- Humans
- Ichthyosis
(diagnosis)
- Mastectomy, Segmental
- Middle Aged
- Neoplasm Staging
- Pigmentation Disorders
(diagnosis)
- Radiodermatitis
(diagnosis)
- Radiotherapy Dosage
- Radiotherapy, Adjuvant
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