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In vivo evaluation method of the effect of nattokinase on carrageenan-induced tail thrombosis in a rat model.

Abstract
Thrombosis is characterized by congenital and acquired procatarxis. Nattokinase inhibits thrombus formation in vitro. However, in vivo evaluation of the therapeutic efficacy of nattokinase against thrombosis remains to be conducted. Subcutaneous nattokinase injections of 1 or 2 mg/ml were administered to the tails of rats. Subsequently, κ-carrageenan was intravenously administered to the tails at 12 h after nattokinase injections. The mean length of the infarcted regions in the tails of rats was significantly shorter in rats administered 2 mg/ml of nattokinase than those in control rats. Nattokinase exhibited significant prophylactic antithrombotic effects. Previously, the in vitro efficacy of nattokinase against thrombosis had been reported; now our study has revealed the in vivo efficacy of nattokinase against thrombosis.
AuthorsSeitaro Kamiya, Masayori Hagimori, Masayoshi Ogasawara, Masayuki Arakawa
JournalActa haematologica (Acta Haematol) Vol. 124 Issue 4 Pg. 218-24 ( 2010) ISSN: 1421-9662 [Electronic] Switzerland
PMID21071931 (Publication Type: Journal Article)
CopyrightCopyright © 2010 S. Karger AG, Basel.
Chemical References
  • Fibrinolytic Agents
  • Carrageenan
  • Subtilisins
  • nattokinase
Topics
  • Animals
  • Carrageenan
  • Disease Models, Animal
  • Female
  • Fibrinolytic Agents (pharmacology, therapeutic use)
  • Infarction (drug therapy)
  • Rats
  • Rats, Wistar
  • Soy Foods
  • Subtilisins (therapeutic use)
  • Tail (blood supply)
  • Thrombosis (chemically induced, drug therapy, prevention & control)

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