Abstract |
A series of coumarin- chalcone hybrids have been synthesized and evaluated for their in vitro cytotoxicity against a panel of four human cancer cell lines and normal fibroblasts (NIH3T3). Among 21 compounds screened, three compounds (23, 25 and 26) showed IC(50) range from 3.59 to 8.12 μM. The most promising compound 26 showed around 30-fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC(50) value of 3.59 μM.
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Authors | Koneni V Sashidhara, Abdhesh Kumar, Manoj Kumar, Jayanta Sarkar, Sudhir Sinha |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 20
Issue 24
Pg. 7205-11
(Dec 15 2010)
ISSN: 1464-3405 [Electronic] England |
PMID | 21071221
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Chalcones
- Coumarins
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Topics |
- Animals
- Antineoplastic Agents
(chemical synthesis, therapeutic use, toxicity)
- Cell Line, Tumor
- Chalcones
(chemistry)
- Coumarins
(chemistry)
- Humans
- Mice
- NIH 3T3 Cells
- Neoplasms
(drug therapy)
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