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Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents.

Abstract
A series of coumarin-chalcone hybrids have been synthesized and evaluated for their in vitro cytotoxicity against a panel of four human cancer cell lines and normal fibroblasts (NIH3T3). Among 21 compounds screened, three compounds (23, 25 and 26) showed IC(50) range from 3.59 to 8.12 μM. The most promising compound 26 showed around 30-fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC(50) value of 3.59 μM.
AuthorsKoneni V Sashidhara, Abdhesh Kumar, Manoj Kumar, Jayanta Sarkar, Sudhir Sinha
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 20 Issue 24 Pg. 7205-11 (Dec 15 2010) ISSN: 1464-3405 [Electronic] England
PMID21071221 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Chalcones
  • Coumarins
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis, therapeutic use, toxicity)
  • Cell Line, Tumor
  • Chalcones (chemistry)
  • Coumarins (chemistry)
  • Humans
  • Mice
  • NIH 3T3 Cells
  • Neoplasms (drug therapy)

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