Modulation of protein kinase signaling cascades by palytoxin.

Abstract

Although known for its acutely toxic action, palytoxin has also been identified as a type of carcinogenic agent called a tumor promoter. In general tumor promoters do not damage DNA, but instead contribute to carcinogenesis by disrupting the regulation of cellular signaling. The identification of palytoxin as a tumor promoter, together with the recognition that the Na(+), K(+)-ATPase is its receptor, led to research on how palytoxin triggers the modulation of signal transduction pathways. This review focuses on mitogen activated protein (MAP) kinases as mediators of palytoxin-stimulated signaling. MAP kinases are a family of serine/threonine kinases that relay a variety of signals to the cellular machinery that regulates cell fate and function. The studies discussed in this review investigated how palytoxin stimulates MAP kinase activity and, in turn, how MAP kinases mediate the response of cells to palytoxin.

• Authors: Elizabeth V Wattenberg
• Journal: Toxicon : official journal of the International Society on Toxinology (Toxicon) Vol. 57 Issue 3 Pg. 440-8 (Mar 01 2011) ISSN: 1879-3150 [Electronic] England
• PMID: 21070801 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Acrylamides
• Carcinogens
• Cnidarian Venoms
• Mitogen-Activated Protein Kinases
• palytoxin
• Calcium

Topics

• Acrylamides (pharmacology, toxicity)
• Calcium (metabolism)
• Carcinogens (pharmacology, toxicity)
• Cell Nucleus (metabolism)
• Cnidarian Venoms
• Mitogen-Activated Protein Kinases (metabolism)
• Neurons (metabolism)
• Signal Transduction (drug effects)