The expression of interferon receptor α/β in human pancreatic cancer in nude mice is essential for tumor response to interferon α treatment.

Abstract

BACKGROUND:

Adjuvant interferon based chemoradiation has rendered promising results against pancreatic cancer. This study evaluated the in vivo effect of interferon α on two human pancreatic carcinoma cell lines implanted in nude.

MATERIAL AND METHODS:

MiaPaCa-2 expressed the interferon α/β receptor and Panc-1 cells did not. Regimen I consisted of intraperitoneal single-agent gemcitabine and Regimen II consisted of IFN-α and gemcitabine biweekly for 30 d.

RESULTS:

Regimen I and II significantly decreased median tumor volume compared with control mice (P < 0.001). However, MiaPaCa-2 showed a more dramatic response to Regimen II compared with Panc-1 implanted mice. MiaPaCa-2 and treated with Regimen II showed less metastasis and less local invasion compared with Panc-1 treated with same regimen. Regimen II was more effective on MiaPaCa-2 compared with Regimen I (P < 0.001). There were no differences between Regimens I and II in the Panc-1 group.

CONCLUSIONS:

Treatment of human pancreatic cancer in nude mice with interferon α and gemcitabine was associated with a reduction in tumor volume. This process was more prominent in the cells that express the interferon receptors.

• Authors: Reza F Saidi, Ahmad Ahad, Jacqueline Tilak, Ilke Nalbantoglu, Michael J Jacobs
• Journal: The Journal of surgical research (J Surg Res) Vol. 173 Issue 2 Pg. 309-13 (Apr 2012) ISSN: 1095-8673 [Electronic] United States
• PMID: 21067774 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Antimetabolites, Antineoplastic
• Immunologic Factors
• Interferon-alpha
• Deoxycytidine
• Receptor, Interferon alpha-beta
• Gemcitabine

Topics

• Animals
• Antimetabolites, Antineoplastic (therapeutic use)
• Carcinoma (drug therapy, metabolism)
• Cell Line, Tumor
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Humans
• Immunologic Factors (therapeutic use)
• Interferon-alpha (therapeutic use)
• Male
• Mice
• Mice, Nude
• Pancreatic Neoplasms (drug therapy, metabolism)
• Receptor, Interferon alpha-beta (metabolism)
• Gemcitabine