Abstract |
To prevent the high turnover bone remodeling associated with acute estrogen deficiency, the bisphosphonate [2-(2-pyridinyl) ethylidene-BP] (2-PEBP) was administered to oophorectomized (OX) rats. Three groups of 15 rats each (250 g) were studied. Group (Gp) A was sham operated, Gp B was OX, and Gp C received 2-PEBP (1.72 mg/kg/day) intraperitoneally for 3 days commencing 4 days postoophorectomy. Oophorectomy was confirmed with serum estradiol measurements. Blood samples were collected on days -7, 0, 7, 14, 21, and 28 for ionized calcium (Ca2+), PTH, and serum bone gla protein (BGP). Rats received tetracycline for bone histomorphometric labeling. All results were compared to Gp A. Body weight increased significantly in Gps B and C (P less than 0.005 by day 28). There was no significant difference in Ca2+, and PTH levels in Gps B and C were similar to Gp A. BGP levels were significantly higher on day 28 in Gp B (P less than 0.05). In Gp C, BGP levels were significantly decreased on days 7, 21, and 28 (P less than 0.03). Gp B revealed increased bone turnover without loss of bone volume (BV/TV). BV/TV was significantly increased in Gp C despite a decrease in parameters of bone formation and normal osteoclast number. In conclusion, 2-PEBP in the OX rat inhibited bone resorption more than formation with resultant hyperostosis. Serum BGP appeared to be a good marker of the changes observed on bone histomorphometry.
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Authors | C Movsowitz, S Epstein, M Fallon, F Ismail, S Thomas |
Journal | Calcified tissue international
(Calcif Tissue Int)
Vol. 46
Issue 3
Pg. 195-9
(Mar 1990)
ISSN: 0171-967X [Print] United States |
PMID | 2106379
(Publication Type: Journal Article)
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Chemical References |
- Diphosphonates
- Parathyroid Hormone
- Osteocalcin
- Estradiol
- 2-(2-pyridyl)ethylidine-1,1-bisphosphonate
- Calcium
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Topics |
- Animals
- Body Weight
(drug effects, physiology)
- Bone Development
(drug effects, physiology)
- Bone Resorption
(chemically induced, physiopathology)
- Calcium
(blood)
- Diphosphonates
(pharmacology)
- Estradiol
(blood)
- Female
- Hyperostosis
(chemically induced, physiopathology)
- Osteocalcin
(blood)
- Ovariectomy
- Parathyroid Hormone
(blood)
- Rats
- Rats, Inbred Strains
- Tibia
(pathology)
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