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TH17 is involved in the remarkable regression of metastatic malignant melanoma to topical diphencyprone.

Abstract
The authors provide an update on a previously reported patient with in-transit metastatic melanoma of the scalp treated with topical diphencyprone (DPCP). Molecular studies implicate the thymus-derived TH17 lymphocyte subset in a remarkable immunotherapeutic regression. The authors performed RT-PCR of total RNA from paraffin-embedded tissue before and after treatment with DPCP. Before treatment with DPCP, the authors found elevated expression of IL 17C/D/E/F; after treatment there was no detectable expression. Conversely, increased expression of PLZF/CD27 and CTLA4 was seen after treatment with no expression before treatment. No expression of IL17A/B, CD7, RORgTand FoxP3 were before or after treatment. Conclusions are limited to only the time samples were obtained. Remarkable regression of an in-transit metastatic melanoma treated with the immunomodulatory agent DPCP showed gain and loss of gene expression of the TH17 pathway. Further study of this pathway from NK to NK-T to TH7 and TH1 cells both with and without accessory or dendritic cells will improve understanding of contact sensitizers as topical immunomodulators.
AuthorsFrank Martiniuk, Diona L Damian, John F Thompson, Richard A Scolyer, Kam-Meng Tchou-Wong, William R Levis
JournalJournal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 9 Issue 11 Pg. 1368-72 (Nov 2010) ISSN: 1545-9616 [Print] United States
PMID21061759 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Antigens, CD
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Cyclopropanes
  • Haptens
  • Interleukin-17
  • Kruppel-Like Transcription Factors
  • Ointments
  • Promyelocytic Leukemia Zinc Finger Protein
  • ZBTB16 protein, human
  • diphenylcyclopropenone
Topics
  • Administration, Topical
  • Aged
  • Antigens, CD (genetics)
  • CTLA-4 Antigen
  • Cyclopropanes (administration & dosage)
  • Haptens (administration & dosage)
  • Humans
  • Interleukin-17 (genetics, metabolism)
  • Kruppel-Like Transcription Factors (genetics)
  • Male
  • Melanoma (drug therapy, genetics, immunology, secondary)
  • Ointments
  • Promyelocytic Leukemia Zinc Finger Protein
  • Reverse Transcriptase Polymerase Chain Reaction
  • Scalp
  • Skin Neoplasms (drug therapy, genetics, immunology, pathology)
  • Th17 Cells (immunology)

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